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課程名稱 |
高等有機化學一
Advanced Organic Chemistry (Ⅰ) |
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開課學期 |
109-1 |
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授課對象 |
理學院 化學所化學組 |
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授課教師 |
柳玗珍 |
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課號 |
Chem7027 |
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課程識別碼 |
223EM1230 |
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班次 |
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學分 |
4.0 |
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全/半年 |
半年 |
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必/選修 |
必修 |
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上課時間 |
星期一3,4(10:20~12:10)星期五3,4(10:20~12:10) |
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上課地點 |
化121化121 |
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備註 |
本課程以英語授課。
限本系所學生(含輔系、雙修生) 且 限碩士班以上
總人數上限：30人 |
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Ceiba 課程網頁 |
http://ceiba.ntu.edu.tw/1091Chem7027_ |
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課程簡介影片 |
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核心能力關聯 |
核心能力與課程規劃關聯圖 |
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課程大綱
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課程概述 |
This course is intended to provide an overview of some reactions commonly employed in synthetic organic chemistry, with an emphasis on carbon-carbon bond forming reactions. Issues related to chemo-, regio-, and stereoselectivity are central to developing synthetic strategies and will be highlighted throughout the course.
This is 4-credit course aimed for students in the M.Sc. and Ph.D. programs in the organic division of the Department of Chemistry. |
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課程目標 |
Tentative Course Outline
1. Functional Group Interconversions
– Substitutions
– Protecting Groups
– Alkene Functionalization
– Reductions
– Oxidations
2. C–C Bond Forming Reactions
– Enolate Formation/Alkylation/Aldol reactions
– Olefinations
– Addition Reactions
– Cycloaddition Reactions
– Pericyclic Reactions
– Carbenes
– Carbocations |
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課程要求 |
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預期每週課後學習時數 |
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Office Hours |
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指定閱讀 |
Carey, Francis A, and Richard J. Sundberg. Advanced Organic Chemistry: Part B: Reactions and Synthesis, 5th Ed. |
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參考書目 |
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評量方式
(僅供參考) |
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週次 |
日期 |
單元主題 |
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Week 1 |
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1. Introduction and Functional Group Interconversion by Substitution, Including Protection and Deprotection (C&S Chapter 3) |
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Week 2 |
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2. Electrophilic Additions to Carbon-Carbon Multiple Bonds (C&S Chapter 4) |
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Week 3 |
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3. Reduction of Carbon-Carbon Multiple Bonds, Carbonyl Groups, and Other Functional Groups (C&S Chapter 5) |
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Week 4 |
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4. Oxidations (C&S Chapter 6) |
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Week 5 |
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5. Alkylation of Enolates and Other Carbon Nucleophiles (C&S Chapter 1) |
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Week 6 |
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Mid-Term I |
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Week 7 |
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6. Reactions of Carbon Nucleophiles with Carbonyl Compounds (C&S Chapter 2) |
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Week 8 |
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7. Carbon-Carbon Bond Forming Reactions of Compounds of Boron, Silicon, and Tin (C&S Chapter 9) |
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Week 9 |
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8. Organometallic Compounds of Group I and II Metals (C&S Chapter 7) |
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Week 10 |
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9. Concerted Cycloadditions, Unimolecular Rearrangements, and Thermal Eliminations (C&S Chapter 6) |
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Week 11 |
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Mid-Term II |
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Week 12 |
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10. Reactions Involving Carbocations, Carbenes, and Radicals and Reactive Intermediates (C&S Chapter 10) |
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Week 13 |
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11. Aromatic Substitution Reactions (C&S Chapter 11) |
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Week 14 |
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12. Reactions Involving Transition Metals (C&S Chapter 8) |
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Week 15 |
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Final Exam |
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Week 16 |
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Oral Presentation |
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Week 17 |
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Oral Presentation |
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